Placental Alpha Hemoglobin Stabilizing Protein (AHSP) and recurrent miscarriage
نویسندگان
چکیده
منابع مشابه
Evaluation of alpha hemoglobin stabilizing protein (AHSP) as a genetic modifier in patients with beta thalassemia.
Although beta thalassemia is considered to be a classic monogenic disease, it is clear that there is considerable clinical variability between patients who inherit identical beta globin gene mutations, suggesting that there may be a variety of genetic determinants influencing different clinical phenotypes. It has been suggested that variations in the structure or amounts of a highly expressed r...
متن کاملPlacental thrombomodulin expression in recurrent miscarriage
BACKGROUND Early pregnancy loss can be associated with trophoblast insufficiency and coagulation defects. Thrombomodulin is an endothelial-associated anticoagulant protein involved in the control of hemostasis and inflammation at the vascular beds and it's also a cofactor of the protein C anticoagulant pathway. DISCUSSION We evaluate the Thrombomodulin expression in placental tissue from spon...
متن کاملAlpha-hemoglobin stabilizing protein: molecular function and clinical correlation.
The discovery of alpha-hemoglobin stabilizing protein (AHSP), a chaperone for free alpha-hemoglobin (alpha-Hb), has provided a satisfactory solution to the perplexing problem of balanced globin levels for Hb production in erythroid cells in the face of a two-fold excess of alpha-globin to beta-globin gene dosage. Unmatched alpha-Hb is unstable and precipitates onto membranes, where the released...
متن کاملAlpha-Hemoglobin-Stabilizing Protein: An Erythroid Molecular Chaperone
Alpha-hemoglobin-stabilizing protein (AHSP) is an erythroid-specific protein that acts as a molecular chaperone for the free α chains of hemoglobin. Evidence strongly suggests that AHSP participates in hemoglobin synthesis and may act to neutralize the cytotoxic effects of excess free alpha-globin subunits that accumulate both in normal and beta-thalassemic erythroid precursor cells. As such, A...
متن کاملAHSP: a novel hemoglobin helper.
Recently, the small protein alpha hemoglobin-stabilizing protein (AHSP) was identified and found to specifically bind alpha-globin, stabilize its structure, and limit the toxic effects of excess alpha-globin, which are manifest in the inherited blood disorder beta thalassemia. In this issue of the JCI, Yu, Weiss, and colleagues show that AHSP is also critical to the formation and stabilization ...
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ژورنال
عنوان ژورنال: Cell Stress and Chaperones
سال: 2008
ISSN: 1355-8145,1466-1268
DOI: 10.1007/s12192-008-0072-y